Article
The human immunodeficiency virus type 1 promoter contains a CATA box instead of a TATA box for optimal transcription and replication.
Journal of virology - 1 Jul 2004
van Opijnen Tim, Kamoschinski Joost, Jeeninga Rienk E, Berkhout Ben
Abstract excerpt
The human immunodeficiency virus type 1 (HIV-1) transcriptional promoter contains a single polymorphism in the TATA box. Most subtypes contain the sequence TATAAGC, but subtype E and some recombinant AG strains have the sequence TAAAAGC. Based on mutagenesis studies of cellular RNA polymerase II (pol II) promoters, it has been proposed that the subtype E TATA box is nonfunctional due to the T-to-A substitution at...
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