apo B gene knockout in mice results in embryonic lethality in homozygotes and neural tube defects, male infertility, and reduced HDL cholesterol ester and apo A-I transport rates in heterozygotes.

Abstract excerpt

apo B is a structural constituent of several classes of lipoprotein particles, including chylomicrons, VLDL, and LDL. To better understand the role of apo B in the body, we have used gene targeting in embryonic stem cells to create a null apo B allele in the mouse. Homozygous apo B deficiency led to embryonic lethality, with resorption of all embryos by gestational day 9. Heterozygotes showed an increased...

Topics

• Alleles
• Animals
• Apolipoprotein A-I
• Apolipoproteins B
• Base Sequence
• Biological Transport
• Cholesterol Esters
• Cholesterol, HDL
• Fetal Death
• Gene Expression Regulation, Developmental