Article
Phenotypic analysis of mice expressing exclusively apolipoprotein B48 or apolipoprotein B100.
Proceedings of the National Academy of Sciences of the United States of America - 25 Jun 1996
Farese R V, Véniant M M, Cham C M, Flynn L M, Pierotti V, Loring J F, Traber M, Ruland S, Stokowski R S, Huszar D, Young S G
Abstract excerpt
Apolipoprotein (apo)-B is found in two forms in mammals: apo-B100, which is made in the liver and the yolk sac, and apo-B48, a truncated protein made in the intestine. To provide models for understanding the physiologic purpose for the two forms of apo-B, we used targeted mutagenesis of the apo-B gene to generate mice that synthesize exclusively apo-B48 (apo-B48-only mice) and mice that synthesize exclusively...
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