Article
Dramatically decreased high density lipoprotein cholesterol, increased remnant clearance, and insulin hypersensitivity in apolipoprotein A-II knockout mice suggest a complex role for apolipoprotein A-II in atherosclerosis susceptibility.
Proceedings of the National Academy of Sciences of the United States of America - 10 Dec 1996
Weng W, Breslow J L
Abstract excerpt
Apolipoprotein (apo) A-II is the second most abundant apolipoprotein in high density lipoprotein (HDL). To study its role in lipoprotein metabolism and atherosclerosis susceptibility, apo A-II knockout mice were created. Homozygous knockout mice had 67% and 52% reductions in HDL cholesterol level...
Topics
- Animals
- Apolipoprotein A-II
- Arteriosclerosis
- Cholesterol, HDL
- Genetic Predisposition to Disease
- Insulin
- Mice
- Mice, Knockout