Article
Targeted modification of the apolipoprotein B gene results in hypobetalipoproteinemia and developmental abnormalities in mice.
Proceedings of the National Academy of Sciences of the United States of America - 15 Mar 1993
Homanics G E, Smith T J, Zhang S H, Lee D, Young S G, Maeda N
Abstract excerpt
Familial hypobetalipoproteinemia is an autosomal codominant disorder resulting in a dramatic reduction in plasma concentrations of apolipoprotein (apo) B, cholesterol, and beta-migrating lipoproteins. A benefit of hypobetalipoproteinemia is that mildly affected individuals may be protected from c...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Apolipoproteins B
- Base Sequence
- Blastocyst
- Brain
- Cholesterol
- Cholesterol, HDL
- Exons
- Female
- Globins