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Article

Zebrafish mutants provide insights into Apolipoprotein B functions during embryonic development and pathological conditions.

JCI insight - 8 Jul 2021

Templehof Hanoch, Moshe Noga, Avraham-Davidi Inbal, Yaniv Karina

Abstract excerpt

Apolipoprotein B (ApoB) is the primary protein of chylomicrons, VLDLs, and LDLs and is essential for their production. Defects in ApoB synthesis and secretion result in several human diseases, including abetalipoproteinemia and familial hypobetalipoproteinemia (FHBL1). In addition, ApoB-related dyslipidemia is linked to nonalcoholic fatty liver disease (NAFLD), a silent pandemic affecting billions globally. Due...

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Identifiers

PMID: 34236046
DOI: 10.1172/jci.insight.130399
PMCID: PMC8410079

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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