Article
Apolipoprotein B RNA editing enzyme-deficient mice are viable despite alterations in lipoprotein metabolism.
Proceedings of the National Academy of Sciences of the United States of America - 9 Jul 1996
Morrison J R, Pászty C, Stevens M E, Hughes S D, Forte T, Scott J, Rubin E M
Abstract excerpt
RNA editing in the nucleus of higher eukaryotes results in subtle changes to the RNA sequence, with the ability to effect dramatic changes in biological function. The first example to be described and among the best characterized, is the cytidine-to-uridine editing of apolipoprotein B (apo-B) RNA. The editing of apo-B RNA is mediated by a novel cytidine deaminase, apobec-1, which has acquired the ability to bind...
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