Article
Exencephaly and hydrocephaly in mice with targeted modification of the apolipoprotein B (Apob) gene.
Teratology - 1 Jan 1995
Homanics G E, Maeda N, Traber M G, Kayden H J, Dehart D B, Sulik K K
Abstract excerpt
Apolipoprotein B (apoB) is a key structural component of several lipoproteins. These lipoproteins transport cholesterol, lipids, and vitamin E in the circulation. Humans that produce truncated forms of apoB have low plasma concentrations of apoB, beta-lipoproteins, cholesterol, and often vitamin E. This condition has been modeled in mice by targeted modification of the apoB gene. Homozygous transgenic mice...
Topics
- Animals
- Apolipoproteins B
- Apoptosis
- Disease Models, Animal
- Female
- Genotype
- Gestational Age
- Hydrocephalus
- Hypobetalipoproteinemias
- Male
- Mice
- Mice, Inbred C57BL