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Article

Genetic abnormalities in sporadic parathyroid adenomas: loss of heterozygosity for chromosome 3q markers flanking the calcium receptor locus.

The Journal of clinical endocrinology and metabolism - 1 Nov 1995

Thompson D B, Samowitz W S, Odelberg S, Davis R K, Szabo J, Heath H

Abstract excerpt

Inactivating mutations of the parathyroid cell calcium receptor (CaR) gene cause one form of familial benign/hypocalciuric hypercalcemia, and in homozygous form, cause neonatal severe primary hyperparathyroidism with parathyroid hyperplasia. Thus, we postulated that partial or total loss of CaR function might contribute to calcium insensitivity or even stimulate cell proliferation in sporadic parathyroid adenomas...

Topics

Adenoma
Alleles
Calcium-Binding Proteins
Chromosome Mapping
Chromosomes, Human, Pair 3
DNA
Genetic Markers
Heterozygote
Humans
Parathyroid Neoplasms

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Identifiers

PMID: 7593455
DOI: 10.1210/jcem.80.11.7593455

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7593455-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Genetic abnormalities in sporadic parathyroid adenomas: loss of heterozygosity for chromosome 3q markers flanking the calcium receptor locus.PMID 7593455Read ↗

No evidence for mutations in the calcium-sensing receptor gene in sporadic parathyroid adenomas.Semantic proximity Read ↗

Allelic imbalance in sporadic parathyroid carcinoma and evidence for its de novo origins.Semantic proximity Read ↗

Tumor-Specific Decreased Expression of Calcium Sensing Receptor Messenger Ribonucleic Acid in Sporadic Primary Hyperparathyroidism<sup>1</sup>Semantic proximity Read ↗

Loss of heterozygosity in sporadic parathyroid tumours: involvement of chromosome 1 and the MEN1 gene locus in 11q13.Semantic proximity Read ↗

Chromosome 3p allele loss in early invasive breast cancer: detailed mapping and association with clinicopathological featuresSemantic proximity Read ↗

Genetic alterations in sporadic renal-cell carcinoma: molecular analyses of tumor suppressor gene harboring chromosomal regions 3p, 5q, and 17p.Semantic proximity Read ↗

Inclusion of new microsatellite repeats in allelic loss analysis excludes retention of heterozygosity in the renal cell carcinoma critical region in 3p21.Semantic proximity Read ↗

Loss of heterozygosity suggests multiple genetic alterations in pheochromocytomas and medullary thyroid carcinomas.Semantic proximity Read ↗

Identification of a 700-kb region of common allelic loss in chromosome bands 3p14.3-p21.1 in human renal cell carcinoma.Semantic proximity Read ↗

Alterations of the MEN1 gene in sporadic parathyroid tumors.Semantic proximity Read ↗

The region of common allelic losses in sporadic renal cell carcinoma is bordered by the loci D3S2 and THRB.Semantic proximity Read ↗

Sporadic hypoparathyroidism caused by de Novo gain-of-function mutations of the Ca(2+)-sensing receptor.Semantic proximity Read ↗

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