Article
Allelic imbalance in sporadic parathyroid carcinoma and evidence for its de novo origins.
Endocrine - 1 Oct 2013
Costa-Guda Jessica, Imanishi Yasuo, Palanisamy Nallasivam, Kawamata Norihiko, Phillip Koeffler H, Chaganti R S K, Arnold Andrew
Abstract excerpt
Parathyroid cancer is a rare, clinically aggressive cause of primary hyperparathyroidism, and whether these malignancies generally evolve from pre-existing benign adenomas or arise de novo is unclear. Furthermore, while inactivation of the CDC73 (HRPT2) tumor suppressor gene, encoding parafibromin, is a major contributor, other genes essential to parathyroid carcinogenesis remain unknown. We sought to identify...
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