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Article

The region of common allelic losses in sporadic renal cell carcinoma is bordered by the loci D3S2 and THRB.

Genomics - 1 Nov 1991

van der Hout A H, van der Vlies P, Wijmenga C, Li F P, Oosterhuis J W, Buys C H

Abstract excerpt

Cytogenetic studies and DNA analysis have shown that the short arm of chromosome 3 is the region in the genome that is commonly deleted in renal cell carcinoma. By studying loss of heterozygosity in 41 matched tumor/normal kidney tissue pairs, we could delimit the commonly deleted part of 3p to the region between the loci THRB (in 3p24) and D3S2 (in 3p21). The regions on 3p suggested to be involved in the Von...

Topics

Alleles
Blotting, Southern
Carcinoma, Renal Cell
Chromosome Deletion
Chromosomes, Human, Pair 3
DNA Probes
DNA, Neoplasm
Heterozygote
Humans
Kidney Neoplasms
Neoplastic Syndromes, Hereditary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Restriction Fragment Length

von Hippel-Lindau Disease

Source

Identifiers

PMID: 1685475
DOI: 10.1016/0888-7543(91)90060-r

Genes

THRB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1685475-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The region of common allelic losses in sporadic renal cell carcinoma is bordered by the loci D3S2 and THRB.PMID 1685475Read ↗

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