Article
Gene RPA43 in Saccharomyces cerevisiae encodes an essential subunit of RNA polymerase I.
The Journal of biological chemistry - 13 Oct 1995
Thuriaux P, Mariotte S, Buhler J M, Sentenac A, Vu L, Lee B S, Nomura M
Abstract excerpt
Yeast RNA polymerase I contains 14 distinct polypeptides, including A43, a component of about 43 kDa. The corresponding gene, RPA43, encodes a 326-amino acid polypeptide matching the peptidic sequence of two tryptic fragments isolated from A43. Gene inactivation leads to a lethal phenotype that is rescued by a plasmid containing the 35S ribosomal RNA gene fused to the GAL7 promoter, which allows the synthesis of...
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