Adenovirus-based p53 gene therapy in ovarian cancer.

doi:10.1006/gyno.1995.0002

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Article

Adenovirus-based p53 gene therapy in ovarian cancer.

Gynecologic oncology - 1 Nov 1995

Santoso J T, Tang D C, Lane S B, Hung J, Reed D J, Muller C Y, Carbone D P, Lucci J A, Miller D S, Mathis J M

Abstract excerpt

Mutations of the p53 tumor suppressor gene are the most common molecular genetic abnormality to be described in ovarian cancer. To determine the feasibility of mutant p53 as a molecular target for gene therapy in ovarian cancer, we constructed an adenovirus vector containing the wild-type p53 gen...

Topics

Adenoviridae
Base Sequence
Female
Gene Expression
Genes, p53
Humans
Molecular Sequence Data
Mutation
Ovarian Neoplasms
Tumor Cells, Cultured
beta-Galactosidase

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