Article
Adenovirus-mediated p53 gene therapy in osteosarcoma cell lines: sensitization to cisplatin and doxorubicin.
Cancer gene therapy - 1 Apr 2006
Ganjavi H, Gee M, Narendran A, Parkinson N, Krishnamoorthy M, Freedman M H, Malkin D
Abstract excerpt
The poor prognosis for patients with metastatic osteosarcoma (OS) indicates that new therapeutic options should be explored. Studies with adenoviral-mediated p53 gene transfer have been conducted in many cancer types including cervical, ovarian, prostatic and head and neck tumors. However, limited work has been carried out with pediatric cancers, including OS. Using three viral constructs containing cDNA for...
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