Article
Three NF-kappa B sites in the I kappa B-alpha promoter are required for induction of gene expression by TNF alpha.
Nucleic acids research - 11 Sept 1994
Ito C Y, Kazantsev A G, Baldwin A S
Abstract excerpt
NF-kappa B was first identified as a postive regulator which bound to a 10 bp sequence in the first intron of the Ig kappa light chain gene. Further characterization of this transcription factor has revealed that NF-kappa B is kept from binding to its consensus sequence by its inhibitor, IkB-alph...
Topics
- Base Sequence
- Binding Sites
- Cloning, Molecular
- DNA
- DNA-Binding Proteins
- Gene Expression Regulation
- HeLa Cells
- Humans
- I-kappa B Proteins
- Molecular Sequence Data
- Mutation
- NF-KappaB Inhibitor alpha
- NF-kappa B
- Promoter Regions, Genetic
- RNA, Messenger
- Sequence Analysis, DNA
- Transcription, Genetic
- Tumor Necrosis Factor-alpha