Article
Three NF-kappa B sites in the I kappa B-alpha promoter are required for induction of gene expression by TNF alpha.
Nucleic acids research - 11 Sept 1994
Ito C Y, Kazantsev A G, Baldwin A S
Abstract excerpt
NF-kappa B was first identified as a postive regulator which bound to a 10 bp sequence in the first intron of the Ig kappa light chain gene. Further characterization of this transcription factor has revealed that NF-kappa B is kept from binding to its consensus sequence by its inhibitor, IkB-alpha, which retains NF-kappa B in the cytoplasm. Upon receiving various extra- and intracellular signals, I kappa B-alpha...
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