Characterization of NF-kappa B/I kappa B proteins in zebra fish and their involvement in notochord development.

Abstract excerpt

Although largely involved in innate and adaptive immunity, NF-kappa B plays an important role in vertebrate development. In chicks, the inactivation of the NF-kappa B pathway induces functional alterations of the apical ectodermal ridge, which mediates limb outgrowth. In mice, the complete absence of NF-kappa B activity leads to prenatal death and neural tube defects. Here, we report the cloning and...

Topics

• Animals
• Cells, Cultured
• DNA, Complementary
• Fetal Proteins
• Gene Expression Regulation, Developmental
• Humans
• I-kappa B Proteins
• Mice
• Mice, Knockout
• NF-KappaB Inhibitor alpha
• NF-kappa B
• Notochord
• Phenotype