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Article

Nuclear factor I-B (Nfib) deficient mice have severe lung hypoplasia.

Mechanisms of development - 1 Mar 2002

Gründer Albert, Ebel Thorsten T, Mallo Moisés, Schwarzkopf Georg, Shimizu Takehiko, Sippel Albrecht E, Schrewe Heinrich

Abstract excerpt

Binding sites for transcription factor nuclear factor one (NFI) proteins, encoded by four genes in the mouse, have been characterized from many tissue-specific genes. NFI genes are expressed in unique but overlapping patterns in embryonic and in adult tissues. Nfib is highly expressed in the embryonic lung. Here we show that Nfib null mutants die early postnatally and display severe lung hypoplasia. Heterozygotes...

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Identifiers

PMID: 11850179
DOI: 10.1016/s0925-4773(01)00640-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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