Extensive allelic sequence variation in the J region of the human immunoglobulin heavy chain gene locus.

doi:10.1002/eji.1830250926

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Article

Extensive allelic sequence variation in the J region of the human immunoglobulin heavy chain gene locus.

European journal of immunology - 1 Sept 1995

Mattila P S, Schugk J, Wu H, Mäkelä O

Abstract excerpt

During the initial stages of B lymphocyte differentiation heavy chain variable (VH), diversity (DH) and joining (JH) gene segments recombine to form a functional heavy chain variable region (VDJ) gene. Evidence for genetic polymorphism of the human JH gene segments has been obtained from mature r...

Topics

Alleles
B-Lymphocytes
Base Sequence
Biological Evolution
Cloning, Molecular
Humans
Immunoglobulin Heavy Chains
Immunoglobulin J-Chains
Molecular Sequence Data

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