Article
Polymorphism and utilization of human VH Genes.
Annals of the New York Academy of Sciences - 29 Sept 1995
Milner E C, Hufnagle W O, Glas A M, Suzuki I, Alexander C
Abstract excerpt
The human VH germline repertoire comprises approximately 100 elements, which can be grouped into seven families based on nucleotide sequence similarity. Members of different families are interspersed throughout the complex, with limited sets of alleles identified for most loci. Linkage disequilib...
Topics
- Alleles
- Bacterial Proteins
- Base Sequence
- Deoxyribonucleases, Type II Site-Specific
- Female
- Gene Frequency
- Gene Rearrangement, B-Lymphocyte, Heavy Chain
- Genes, Immunoglobulin
- Haplotypes
- Humans
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region
- Male
- Molecular Sequence Data
- Polymorphism, Restriction Fragment Length
- Sequence Deletion