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Article

Segmental duplication as one of the driving forces underlying the diversity of the human immunoglobulin heavy chain variable gene region

27 Jan 2011

Abstract excerpt

BACKGROUND: Segmental duplication and deletion were implicated for a region containing the human immunoglobulin heavy chain variable (IGHV) gene segments, 1.9III/hv3005 (possible allelic variants of IGHV3-30) and hv3019b9 (a possible allelic variant of IGHV3-33). However, very little is known about the ranges of the duplication and the polymorphic region. This is mainly because of the difficulty associated with...

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PMID: 21272357
DOI: 10.1186/1471-2164-12-78

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