Article
Individual variation in the germline Ig gene repertoire inferred from variable region gene rearrangements.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2010
Boyd Scott D, Gaëta Bruno A, Jackson Katherine J, Fire Andrew Z, Marshall Eleanor L, Merker Jason D, Maniar Jay M, Zhang Lyndon N, Sahaf Bita, Jones Carol D, Simen Birgitte B, Hanczaruk Bozena, Nguyen Khoa D, Nadeau Kari C, Egholm Michael, Miklos David B, Zehnder James L, Collins Andrew M
Abstract excerpt
Individual variation in the Ig germline gene repertoire leads to individual differences in the combinatorial diversity of the Ab repertoire, but the study of such variation has been problematic. The application of high-throughput DNA sequencing to the study of rearranged Ig genes now makes this possible. The sequencing of thousands of VDJ rearrangements from an individual, either from genomic DNA or expressed...
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