Article
Neuroendocrine cell type-specific and inducible expression of the secretogranin II gene: crucial role of cyclic adenosine monophosphate and serum response elements.
Endocrinology - 1 Feb 1999
Mahata S K, Mahata M, Livsey C V, Gerdes H H, Huttner W B, O'Connor D T
Abstract excerpt
Secretogranin II, an acidic protein in the chromogranin/secretogranin family, is widely distributed in neuroendocrine secretory granules. What factors govern such widespread, yet selective, expression? The 5' deletions localized neuroendocrine cell type-specific expression to the proximal mouse s...
Topics
- Animals
- Base Sequence
- Blood
- Chromogranins
- Cyclic AMP
- Gene Deletion
- Gene Expression Regulation
- Mice
- Molecular Sequence Data
- Mutation
- Neurosecretory Systems
- PC12 Cells
- Promoter Regions, Genetic
- Proteins
- Rats
- Response Elements
- Transfection