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Article

Novel Cyclic Adenosine 3′,5′- Monophosphate Response Element in the Human Chorionic Gonadotropin β-Subunit Gene

1 May 1991

Abstract excerpt

CG is encoded by separate alpha- and beta-subunit genes. Expression of both genes is stimulated by cAMP, but the kinetics of activation are different, with cAMP stimulation of the alpha gene preceding that of the beta gene. The cAMP response element (CRE) in the alpha gene contains a palindromic DNA sequence, TGACGTCA, that binds the transcription factor CREB, a nuclear phosphoprotein that is activated by protein...

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Identifiers

PMID: 1649392
DOI: 10.1210/mend-5-5-693

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