Article
Survival of inner ear sensory neurons in trk mutant mice.
Mechanisms of development - 1 Jun 1997
Schimmang T, Alvarez-Bolado G, Minichiello L, Vazquez E, Giraldez F, Klein R, Represa J
Abstract excerpt
Analysis of trkB-/-; trkC-/- double mutant mice revealed that peripheral and central inner ear sensory neurons are affected in these mice. However, a substantial amount of cochlear and vestibular neurons survive, possibly due to maintenance or upregulation of TrkA expression. To clarify the funct...
Topics
- Animals
- Base Sequence
- Cell Survival
- Cochlea
- DNA Primers
- Ear, Inner
- In Situ Hybridization
- Mice
- Mice, Knockout
- Neurons, Afferent
- Phenotype
- Proto-Oncogene Proteins
- Receptor Protein-Tyrosine Kinases
- Receptor, Ciliary Neurotrophic Factor
- Receptor, trkA
- Receptor, trkC
- Receptors, Nerve Growth Factor
- Vestibule, Labyrinth