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Article

Pathological hypertrophy amelioration by PRAS40-mediated inhibition of mTORC1.

Proceedings of the National Academy of Sciences of the United States of America - 30 Jul 2013

Völkers Mirko, Toko Haruhiro, Doroudgar Shirin, Din Shabana, Quijada Pearl, Joyo Anya Y, Ornelas Luis, Joyo Eri, Thuerauf Donna J, Konstandin Mathias H, Gude Natalie, Glembotski Christopher C, Sussman Mark A

Abstract excerpt

Mechanistic target of rapamycin complex 1 (mTORC1), necessary for cellular growth, is regulated by intracellular signaling mediating inhibition of mTORC1 activation. Among mTORC1 regulatory binding partners, the role of Proline Rich AKT Substrate of 40 kDa (PRAS40) in controlling mTORC1 activity and cellular growth in response to pathological and physiological stress in the heart has never been addressed. This...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23842089
DOI: 10.1073/pnas.1301455110
PMCID: PMC3732982

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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