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Article

mTOR regulates skeletal muscle regeneration in vivo through kinase-dependent and kinase-independent mechanisms.

American journal of physiology. Cell physiology - 1 Dec 2009

Ge Yejing, Wu Ai-Luen, Warnes Christine, Liu Jianming, Zhang Chongben, Kawasome Hideki, Terada Naohiro, Boppart Marni D, Schoenherr Christopher J, Chen Jie

Abstract excerpt

Rapamycin-sensitive signaling is required for skeletal muscle differentiation and remodeling. In cultured myoblasts, the mammalian target of rapamycin (mTOR) has been reported to regulate differentiation at different stages through distinct mechanisms, including one that is independent of mTOR kinase activity. However, the kinase-independent function of mTOR remains controversial, and no in vivo studies have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19794149
DOI: 10.1152/ajpcell.00248.2009
PMCID: PMC2793064

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