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Article

Mnk1 is required for angiotensin II-induced protein synthesis in vascular smooth muscle cells.

Circulation research - 12 Dec 2003

Ishida Mari, Ishida Takafumi, Nakashima Hidekatsu, Miho Narimasa, Miyagawa Kiyoshi, Chayama Kazuaki, Oshima Tetsuya, Kambe Masayuki, Yoshizumi Masao

Abstract excerpt

Angiotensin II (Ang II) stimulates protein synthesis in vascular smooth muscle cells (VSMCs), possibly secondary to regulatory changes at the initiation of mRNA translation. Mitogen-activated protein (MAP) kinase signal-integrating kinase-1 (Mnk1), a substrate of ERK and p38 MAP kinase, phosphorylates eukaryotic initiation factor 4E (eIF4E), an important factor in translation. The goal of the present study was to...

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Identifiers

PMID: 14605021
DOI: 10.1161/01.RES.0000105570.34585.F2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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