cDNA and genomic sequences for rat 8-oxo-dGTPase that prevents occurrence of spontaneous mutations due to oxidation of guanine nucleotides.

doi:10.1093/carcin/16.10.2343

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Article

cDNA and genomic sequences for rat 8-oxo-dGTPase that prevents occurrence of spontaneous mutations due to oxidation of guanine nucleotides.

Carcinogenesis - 1 Oct 1995

Cai J P, Kakuma T, Tsuzuki T, Sekiguchi M

Abstract excerpt

The enzyme, 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase (8-oxo-dGTPase), is present in various organisms and plays an important role in control of spontaneous mutagenesis. This enzyme degrades 8-oxoguanine-containing deoxyribonucleoside triphosphate, a potentially mutagenic substrate for DNA synthesis, to the corresponding monophosphate. To obtain appropriate probes for expression of the gene in various...

Topics

Amino Acid Sequence
Animals
Bacteria
Base Sequence
Cell Line
Cloning, Molecular
DNA Primers
DNA Repair Enzymes
DNA, Complementary
Escherichia coli
Exons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Guanine Nucleotides

Humans

Molecular Sequence Data

Mutation

Oxidation-Reduction

Phosphoric Monoester Hydrolases

Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 7586133
DOI: 10.1093/carcin/16.10.2343

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7586133-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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