Article
Repair of oxidized purines and damaged pyrimidines by E. coli Fpg protein: different roles of proline 2 and lysine 57 residues.
Environmental and molecular mutagenesis - 1 Jan 2002
Saparbaev Murat, Sidorkina Olga M, Jurado Juan, Privezentzev Cyril V, Greenberg Marc M, Laval Jacques
Abstract excerpt
The Escherichia coli Fpg protein is involved in the repair of oxidized purines, including the highly mutagenic 7,8-dihydro-8-oxoguanine (8-oxoG). The Fpg protein also excises various oxidized pyrimidines with high efficiency. We examined, by targeted mutagenesis, the role of two highly conserved amino acid residues, proline 2 (P2) and lysine 57 (K57), on the catalytic activities of the Fpg protein toward a...
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