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Article

Functional expression of TrkA receptors in hippocampal neurons.

Journal of neuroscience research - 1 Nov 1998

Aibel L, Martin-Zanca D, Perez P, Chao M V

Abstract excerpt

Nerve growth factor (NGF) initiates its biological effects by promoting the dimerization and activation of the tyrosine kinase receptor TrkA. The requirements for NGF signaling through the TrkA receptor have been defined extensively from studies in immortalized cells, involving transfection of NIH 3T3, COS, and PC12 cells. In the present study, we tested the effects of extracellular and intracellular mutations of...

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Identifiers

PMID: 9819147
DOI: 10.1002/(SICI)1097-4547(19981101)54:3<424::AID-JNR13>3.0.CO;2-6

Genes

NGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Functional expression of TrkA receptors in hippocampal neurons.PMID 9819147Read ↗

TrkA NGF receptor plays a role in the modulation of p75NTR expression.Semantic proximity Read ↗

A dominant role of the juxtamembrane region of the TrkA nerve growth factor receptor during neuronal cell differentiation.Semantic proximity Read ↗

Molecular dissection of TrkA signal transduction pathways mediating differentiation in human neuroblastoma cells.Semantic proximity Read ↗

TrkA tyrosine residues involved in NGF-induced neurite outgrowth of PC12 cells.Semantic proximity Read ↗

Nerve growth factor induced stimulation of Ras requires Trk interaction with Shc but does not involve phosphoinositide 3-OH kinase.Semantic proximity Read ↗

Differences in early and late responses between neurotrophin-stimulated trkA- and trkC-transfected SH-SY5Y neuroblastoma cells.Semantic proximity Read ↗

A novel mutation within the extracellular domain of TrkA causes constitutive receptor activation.Semantic proximity Read ↗

Down-regulation of the neurotrophin receptor TrkB following ligand binding. Evidence for an involvement of the proteasome and differential regulation of TrkA and TrkB.Semantic proximity Read ↗

Deletions in the extracellular domain of rat trkA lead to an altered differentiative phenotype in neurotrophin responsive cells.Semantic proximity Read ↗

Activation of STAT5-dependent transcription by the neurotrophin receptor Trk.Semantic proximity Read ↗

Constitutively active TrkB confers an aggressive transformed phenotype to a neural crest-derived cell line.Semantic proximity Read ↗

Disruption of NGF binding to the low affinity neurotrophin receptor p75LNTR reduces NGF binding to TrkA on PC12 cells.Semantic proximity Read ↗

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