Functional expression of TrkA receptors in hippocampal neurons.

doi:10.1002/(SICI)1097-4547(19981101)54:3<424::AID-JNR13>3.0.CO;2-6

Back to search

Article

Functional expression of TrkA receptors in hippocampal neurons.

Journal of neuroscience research - 1 Nov 1998

Aibel L, Martin-Zanca D, Perez P, Chao M V

Abstract excerpt

Nerve growth factor (NGF) initiates its biological effects by promoting the dimerization and activation of the tyrosine kinase receptor TrkA. The requirements for NGF signaling through the TrkA receptor have been defined extensively from studies in immortalized cells, involving transfection of NI...

Topics

Adaptor Proteins, Signal Transducing
Adaptor Proteins, Vesicular Transport
Animals
Cell Line
Cell Size
Cells, Cultured
Hippocampus
Humans
Isoenzymes
Mutation
Nerve Growth Factors
Neurites
Neurons
Phospholipase C gamma
Proteins
Proto-Oncogene Proteins
Rats
Rats, Sprague-Dawley

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.