Article
Constitutively active TrkB confers an aggressive transformed phenotype to a neural crest-derived cell line.
Oncogene - 20 Feb 2014
Dewitt J, Ochoa V, Urschitz J, Elston M, Moisyadi S, Nishi R
Abstract excerpt
Neuroblastoma arises from sympathoadrenal progenitors of the neural crest and expression of the neurotrophin receptor TrkB and its ligand, brain-derived neurotrophic factor (BDNF), is correlated with poor prognosis. Although activated TrkB signaling promotes a more aggressive phenotype in established neuroblastoma cell lines, whether TrkB signaling is sufficient to transform neural crest-derived cells has not...
Topics
- Animals
- Cell Transformation, Neoplastic
- Gene Expression
- Immunoglobulins
- Neural Crest
- PC12 Cells
- Phenotype
- Rats
- Receptor, trkB
- Signal Transduction