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Article

Constitutively active TrkB confers an aggressive transformed phenotype to a neural crest-derived cell line.

Oncogene - 20 Feb 2014

Dewitt J, Ochoa V, Urschitz J, Elston M, Moisyadi S, Nishi R

Abstract excerpt

Neuroblastoma arises from sympathoadrenal progenitors of the neural crest and expression of the neurotrophin receptor TrkB and its ligand, brain-derived neurotrophic factor (BDNF), is correlated with poor prognosis. Although activated TrkB signaling promotes a more aggressive phenotype in established neuroblastoma cell lines, whether TrkB signaling is sufficient to transform neural crest-derived cells has not...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23455321
DOI: 10.1038/onc.2013.39
PMCID: PMC3930615

Genes

BDNF
MYCN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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