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Article

Loss of proliferative capacity and induction of senescence in oxidatively stressed human fibroblasts.

The Journal of biological chemistry - 19 Nov 2004

Chen Jian-Hua, Stoeber Kai, Kingsbury Sarah, Ozanne Susan E, Williams Gareth H, Hales C Nicholas

Abstract excerpt

Cellular senescence can result from short, dysfunctional telomeres, oxidative stress, or oncogene expression, and may contribute to aging. To investigate the role of cellular senescence in aging it is necessary to define the time-dependent molecular events by which it is characterized. Here we investigated changes in levels of key proteins involved in cell cycle regulation, DNA replication, and stress resistance...

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PMID: 15377661
DOI: 10.1074/jbc.M409153200

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SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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