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Article

Allele-selective inhibition of expression of huntingtin and ataxin-3 by RNA duplexes containing unlocked nucleic acid substitutions.

Biochemistry - 23 Dec 2013

Aiba Yuichiro, Hu Jiaxin, Liu Jing, Xiang Qin, Martinez Carlos, Corey David R

Abstract excerpt

Unlocked nucleic acid (UNA) is an acyclic analogue of RNA that can be introduced into RNA or DNA oligonucleotides. The increased flexibility conferred by the acyclic structure fundamentally affects the strength of base pairing, creating opportunities for improved applications and new insights into molecular recognition. Here we test how UNA substitutions affect allele-selective inhibition of expression of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24266403
DOI: 10.1021/bi4014209
PMCID: PMC3893079

Genes

AGO2
HTT

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