Article
Functional analysis of a new polymorphism in the human TNF alpha gene promoter.
Scandinavian journal of immunology - 1 Oct 1995
Pociot F, D'Alfonso S, Compasso S, Scorza R, Richiardi P M
Abstract excerpt
In this paper the functional relevance of a TNFA promoter polymorphism, a G/A polymorphic sequence at position -238, was tested by analysing its influence on TNF alpha production upon in vitro stimulation of monocytes from 78 healthy, unrelated individuals by lipopolysaccharide (LPS) or after allogenic stimulation in a panel of 32 healthy individuals. All TNFA-A positive individuals were either DR3 or DR7...
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