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Article

A general strategy for producing conditional alleles of Src-like tyrosine kinases.

Proceedings of the National Academy of Sciences of the United States of America - 10 Oct 1995

Spencer D M, Graef I, Austin D J, Schreiber S L, Crabtree G R

Abstract excerpt

The Src-like tyrosine kinases require membrane localization for transformation and probably for their normal role in signal transduction. We utilized this characteristic to prepare Src-like tyrosine kinases that can be readily activated with the rationally designed chemical inducer of dimerization FK1012. Dimerization of cytoplasmic Src-like tyrosine kinases was not sufficient for signaling, but their recruitment...

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Identifiers

PMID: 7568222
DOI: 10.1073/pnas.92.21.9805
PMCID: PMC40891

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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