Creating conditional mutations in mammals.

Abstract excerpt

For many years geneticists have relied on conditional activation to study the roles of cytolytic or cytostatic proteins in lower eukaryotes or to elucidate the epistatic relationships of proteins in a signaling pathway. Regardless of their merits, conditional mutants have only been available to mammalian geneticists within the past few years. Moreover, the approaches that exist are still limited to a subset of...

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