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Article

Signal transduction in T lymphocytes using a conditional allele of Sos.

Proceedings of the National Academy of Sciences of the United States of America - 10 Oct 1995

Holsinger L J, Spencer D M, Austin D J, Schreiber S L, Crabtree G R

Abstract excerpt

While Ras activation has been shown to play an important role in signal transduction by the T-lymphocyte antigen receptor, the mechanism of its activation in T cells is unclear. Membrane localization of the guanine nucleotide exchange factor Sos, but not Vav or Dbl, was sufficient for Ras-mediated signaling in T lymphocytes. Activation of Sos appears to involve membrane recruitment and not allosteric changes,...

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Identifiers

PMID: 7568223
DOI: 10.1073/pnas.92.21.9810
PMCID: PMC40892

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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