Article
Signal transduction in T lymphocytes using a conditional allele of Sos.
Proceedings of the National Academy of Sciences of the United States of America - 10 Oct 1995
Holsinger L J, Spencer D M, Austin D J, Schreiber S L, Crabtree G R
Abstract excerpt
While Ras activation has been shown to play an important role in signal transduction by the T-lymphocyte antigen receptor, the mechanism of its activation in T cells is unclear. Membrane localization of the guanine nucleotide exchange factor Sos, but not Vav or Dbl, was sufficient for Ras-mediated signaling in T lymphocytes. Activation of Sos appears to involve membrane recruitment and not allosteric changes,...
Topics
- Adaptor Proteins, Signal Transducing
- Alleles
- Amino Acid Sequence
- Cell Compartmentation
- Cell Line
- Dose-Response Relationship, Drug
- Fluorescent Antibody Technique
- GRB2 Adaptor Protein
- Guanine Nucleotide Exchange Factors
- Humans