Article
Design of allele-specific inhibitors to probe protein kinase signaling.
Current biology : CB - 26 Feb 1998
Bishop A C, Shah K, Liu Y, Witucki L, Kung C, Shokat K M
Abstract excerpt
BACKGROUND: Deconvoluting protein kinase signaling pathways using conventional genetic and biochemical approaches has been difficult because of the overwhelming number of closely related kinases. If cell-permeable inhibitors of individual kinases could be designed, the role of each kinase could be systematically assessed. RESULTS: We have devised an approach combining chemistry and genetics to develop the first...
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