Article
Design of allele-specific inhibitors to probe protein kinase signaling.
Current biology : CB - 26 Feb 1998
Bishop A C, Shah K, Liu Y, Witucki L, Kung C, Shokat K M
Abstract excerpt
BACKGROUND: Deconvoluting protein kinase signaling pathways using conventional genetic and biochemical approaches has been difficult because of the overwhelming number of closely related kinases. If cell-permeable inhibitors of individual kinases could be designed, the role of each kinase could b...
Topics
- 3T3 Cells
- Adenosine Triphosphate
- Alleles
- Animals
- Drug Design
- Mice
- Models, Chemical
- Models, Molecular
- Oncogene Protein pp60(v-src)
- Protein Engineering
- Protein Kinases
- Signal Transduction
- Substrate Specificity
- src-Family Kinases