Article
BiP and Sec63p are required for both co- and posttranslational protein translocation into the yeast endoplasmic reticulum.
Proceedings of the National Academy of Sciences of the United States of America - 10 Oct 1995
Brodsky J L, Goeckeler J, Schekman R
Abstract excerpt
Two interacting heat shock cognate proteins in the lumen of the yeast endoplasmic reticulum (ER), Sec63p and BiP (Kar2p), are required for posttranslational translocation of yeast alpha-factor precursor in vitro. To investigate the role of these proteins in cotranslational translocation, we exami...
Topics
- Biological Transport
- Endoplasmic Reticulum
- Fungal Proteins
- Glycoside Hydrolases
- HSP70 Heat-Shock Proteins
- Heat-Shock Proteins
- Membrane Proteins
- Membrane Transport Proteins
- Microsomes
- Models, Biological
- Mutation
- Protein Processing, Post-Translational
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins