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Article

BiP and Sec63p are required for both co- and posttranslational protein translocation into the yeast endoplasmic reticulum.

Proceedings of the National Academy of Sciences of the United States of America - 10 Oct 1995

Brodsky J L, Goeckeler J, Schekman R

Abstract excerpt

Two interacting heat shock cognate proteins in the lumen of the yeast endoplasmic reticulum (ER), Sec63p and BiP (Kar2p), are required for posttranslational translocation of yeast alpha-factor precursor in vitro. To investigate the role of these proteins in cotranslational translocation, we examined the import of invertase into wild-type, sec63, and kar2 mutant yeast membranes. We found that Sec63p and Kar2p are...

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Identifiers

PMID: 7568189
DOI: 10.1073/pnas.92.21.9643
PMCID: PMC40858

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BiP and Sec63p are required for both co- and posttranslational protein translocation into the yeast endoplasmic reticulum.PMID 7568189Read ↗

Interaction between BiP and Sec63p is required for the completion of protein translocation into the ER of Saccharomyces cerevisiae.Semantic proximity Read ↗

Sec63p and Kar2p are required for the translocation of SRP-dependent precursors into the yeast endoplasmic reticulum in vivo.Semantic proximity Read ↗

Genetic interactions between KAR2 and SEC63, encoding eukaryotic homologues of DnaK and DnaJ in the endoplasmic reticulum.Semantic proximity Read ↗

Suppression of a sec63 mutation identifies a novel component of the yeast endoplasmic reticulum translocation apparatus.Semantic proximity Read ↗

ER membrane protein complex required for nuclear fusion.Semantic proximity Read ↗

Specific molecular chaperone interactions and an ATP-dependent conformational change are required during posttranslational protein translocation into the yeast ER.Semantic proximity Read ↗

The Brl domain in Sec63p is required for assembly of functional endoplasmic reticulum translocons.Semantic proximity Read ↗

Sec61p serves multiple roles in secretory precursor binding and translocation into the endoplasmic reticulum membrane.Semantic proximity Read ↗

Genetic interactions between KAR7/SEC71, KAR8/JEM1, KAR5, and KAR2 during nuclear fusion in Saccharomyces cerevisiae.Semantic proximity Read ↗

Loss of BiP/GRP78 function blocks translocation of secretory proteins in yeast.Semantic proximity Read ↗

Interactions between Sec complex and prepro-alpha-factor during posttranslational protein transport into the endoplasmic reticulum.Semantic proximity Read ↗

Protein translocation mutants defective in the insertion of integral membrane proteins into the endoplasmic reticulum.Semantic proximity Read ↗

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