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Article

Specific molecular chaperone interactions and an ATP-dependent conformational change are required during posttranslational protein translocation into the yeast ER.

Molecular biology of the cell - 1 Dec 1998

McClellan A J, Endres J B, Vogel J P, Palazzi D, Rose M D, Brodsky J L

Abstract excerpt

The posttranslational translocation of proteins across the endoplasmic reticulum (ER) membrane in yeast requires ATP hydrolysis and the action of hsc70s (DnaK homologues) and DnaJ homologues in both the cytosol and ER lumen. Although the cytosolic hsc70 (Ssa1p) and the ER lumenal hsc70 (BiP) are homologous, they cannot substitute for one another, possibly because they interact with specific DnaJ homologues on...

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Identifiers

PMID: 9843586
DOI: 10.1091/mbc.9.12.3533
PMCID: PMC25671

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Specific molecular chaperone interactions and an ATP-dependent conformational change are required during posttranslational protein translocation into the yeast ER.PMID 9843586Read ↗

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J domain co-chaperone specificity defines the role of BiP during protein translocation.Semantic proximity Read ↗

Two alternative binding mechanisms connect the protein translocation Sec71-Sec72 complex with heat shock proteins.Semantic proximity Read ↗

Nucleotide exchange factor for the yeast Hsp70 molecular chaperone Ssa1p.Semantic proximity Read ↗

Binding of secretory precursor polypeptides to a translocon subcomplex is regulated by BiP.Semantic proximity Read ↗

Mutations in the Yeast Hsp70, Ssa1, at P417 Alter ATP Cycling, Interdomain Coupling, and Specific Chaperone Functions.Semantic proximity Read ↗

The function of the yeast molecular chaperone Sse1 is mechanistically distinct from the closely related hsp70 family.Semantic proximity Read ↗

The Sec63p J-domain is required for ERAD of soluble proteins in yeast.Semantic proximity Read ↗

Sec61p serves multiple roles in secretory precursor binding and translocation into the endoplasmic reticulum membrane.Semantic proximity Read ↗

Distinct domains within yeast Sec61p involved in post-translational translocation and protein dislocation.Semantic proximity Read ↗

The Brl domain in Sec63p is required for assembly of functional endoplasmic reticulum translocons.Semantic proximity Read ↗

The molecular mechanisms underlying BiP-mediated gating of the Sec61 translocon of the endoplasmic reticulum.Semantic proximity Read ↗

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