Article
Specific molecular chaperone interactions and an ATP-dependent conformational change are required during posttranslational protein translocation into the yeast ER.
Molecular biology of the cell - 1 Dec 1998
McClellan A J, Endres J B, Vogel J P, Palazzi D, Rose M D, Brodsky J L
Abstract excerpt
The posttranslational translocation of proteins across the endoplasmic reticulum (ER) membrane in yeast requires ATP hydrolysis and the action of hsc70s (DnaK homologues) and DnaJ homologues in both the cytosol and ER lumen. Although the cytosolic hsc70 (Ssa1p) and the ER lumenal hsc70 (BiP) are...
Topics
- Adenosine Triphosphatases
- Adenosine Triphosphate
- Base Sequence
- Biological Transport, Active
- DNA Primers
- Endoplasmic Reticulum
- Fungal Proteins
- HSP40 Heat-Shock Proteins
- HSP70 Heat-Shock Proteins
- Heat-Shock Proteins
- Intracellular Membranes
- Membrane Proteins
- Membrane Transport Proteins