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Article

Genetic interactions between KAR7/SEC71, KAR8/JEM1, KAR5, and KAR2 during nuclear fusion in Saccharomyces cerevisiae.

Molecular biology of the cell - 1 Mar 1999

Brizzio V, Khalfan W, Huddler D, Beh C T, Andersen S S, Latterich M, Rose M D

Abstract excerpt

During mating of Saccharomyces cerevisiae, two nuclei fuse to produce a single diploid nucleus. Two genes, KAR7 and KAR8, were previously identified by mutations that cause defects in nuclear membrane fusion. KAR7 is allelic to SEC71, a gene involved in protein translocation into the endoplasmic reticulum. Two other translocation mutants, sec63-1 and sec72Delta, also exhibited moderate karyogamy defects....

Topics

Alleles
Biological Transport
Cell Nucleus
Endoplasmic Reticulum
Fungal Proteins
Gene Dosage
Gene Expression Regulation, Fungal
HSP40 Heat-Shock Proteins
HSP70 Heat-Shock Proteins
Heat-Shock Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Fusion

Membrane Glycoproteins

Membrane Proteins

Membrane Transport Proteins

Microscopy, Electron

Molecular Chaperones

Mutation

Nuclear Envelope

Source

Open in PubMed Open full text

Identifiers

PMID: 10069807
DOI: 10.1091/mbc.10.3.609
PMCID: PMC25191

Genes

SEC63

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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