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Article

p16 proteins from melanoma-prone families are deficient in binding to Cdk4.

Oncogene - 21 Sept 1995

Reymond A, Brent R

Abstract excerpt

The tumor suppressor candidate p16INK4 is a cyclin-dependent kinase inhibitor that inhibits cell proliferation. The p16 coding gene is often mutated in glioblastomas, pancreatic adenocarcinomas and melanoma-prone pedigrees, but, until recently, the significance of these allelic variants has remained unclear. Here, we used interaction mating and coprecipitation to measure interaction of seven p16 allelic variants...

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Identifiers

PMID: 7566978

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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p16 proteins from melanoma-prone families are deficient in binding to Cdk4.PMID 7566978Read ↗

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