p16 proteins from melanoma-prone families are deficient in binding to Cdk4.

Article

p16 proteins from melanoma-prone families are deficient in binding to Cdk4.

Oncogene - 21 Sept 1995

Reymond A, Brent R

Abstract excerpt

The tumor suppressor candidate p16INK4 is a cyclin-dependent kinase inhibitor that inhibits cell proliferation. The p16 coding gene is often mutated in glioblastomas, pancreatic adenocarcinomas and melanoma-prone pedigrees, but, until recently, the significance of these allelic variants has remai...

Topics

Alleles
Carrier Proteins
Cyclin-Dependent Kinase 4
Cyclin-Dependent Kinase 6
Cyclin-Dependent Kinase Inhibitor p16
Cyclin-Dependent Kinases
Cyclins
Enzyme Inhibitors
Humans
Melanoma
Mutation
Protein Kinase Inhibitors
Protein Serine-Threonine Kinases
Proto-Oncogene Proteins

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