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Article

Several noncontiguous domains of CDK4 are involved in binding to the P16 tumor suppressor protein.

Biochemical and biophysical research communications - 19 Aug 1998

Ceha H M, Nasser I, Medema R H, Slebos R J

Abstract excerpt

Cyclin-dependent kinase 4 (CDK4) is a key molecule in the regulation of cell cycle progression at the G1-S phase restriction point. Its activity is specifically regulated by p16 (also known as p16/CDKN2A, p16(INK4a), and MTS1), a tumor suppressor frequently altered in human cancers. A specific mutation in CDK4 codon 24 (Arginine to Cysteine) prevents p16 binding and thus inhibition by p16. This mutated CDK4 acts...

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Source

Identifiers

PMID: 9712735
DOI: 10.1006/bbrc.1998.9183

Genes

CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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