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Article

Several noncontiguous domains of CDK4 are involved in binding to the P16 tumor suppressor protein.

Biochemical and biophysical research communications - 19 Aug 1998

Ceha H M, Nasser I, Medema R H, Slebos R J

Abstract excerpt

Cyclin-dependent kinase 4 (CDK4) is a key molecule in the regulation of cell cycle progression at the G1-S phase restriction point. Its activity is specifically regulated by p16 (also known as p16/CDKN2A, p16(INK4a), and MTS1), a tumor suppressor frequently altered in human cancers. A specific mu...

Topics

Arginine
Cyclin-Dependent Kinase 4
Cyclin-Dependent Kinase Inhibitor p16
Cyclin-Dependent Kinases
Cysteine
Glutathione Transferase
Humans
Melanoma
Mutagenesis, Site-Directed
Mutation
Proto-Oncogene Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Recombinant Fusion Proteins

Structure-Activity Relationship

Tyrosine

Source

Identifiers

PMID: 9712735
DOI: 10.1006/bbrc.1998.9183

Genes

CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9712735-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Several noncontiguous domains of CDK4 are involved in binding to the P16 tumor suppressor protein.PMID 9712735Read ↗

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Role of the p16 tumor suppressor gene in cancer.Semantic proximity Read ↗

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The tumor suppressor protein p16INK4a.Semantic proximity Read ↗

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