Article
Somatic mutations in the brain: relationship to aging?
Mutation research - 1 Oct 1995
Evans D A, Burbach J P, van Leeuwen F W
Abstract excerpt
Genetic instability is generally thought to underlie the process of aging and is predominantly associated with meiosis and mitosis. This review will discuss DNA damage and repair, somatic mutations and somatic recombination events in non-dividing neurons in relation to aging. In general it can be concluded that mutagenesis operates at high frequency in the brain. Present data do not provide clear evidence for...
Topics
- Aging
- Amino Acid Sequence
- Animals
- Base Sequence
- Brain
- Cell Division
- Cockayne Syndrome
- DNA Damage
- DNA Repair
- Humans
- Molecular Sequence Data
- Mutation