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Free radical induced oxidative damage to DNA: relation to brain aging and neurological disorders.

Indian journal of biochemistry & biophysics - 1 Feb 2009

Rao Kalluri Subba

Abstract excerpt

Free radicals are produced in cells by cellular metabolism and by exogenous agents. These species react with biomolecules in cells and one of the important targets is DNA. This kind of damage, often referred to as oxidative DNA damage, has consequences in various organs and particularly in brain, in view of its high metabolic activity and oxygen consumption. The consequences include mutagenesis of various kinds...

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PMID: 19374248

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