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Article

Relevance of 'adaptive' mutations arising in non-dividing cells of microorganisms to age-related changes in mutant phenotypes of neurons.

Trends in neurosciences - 1 Nov 1997

Finch C E, Goodman M F

Abstract excerpt

Brattleboro rats do not produce vasopressin (VP) because of a germ-line single-base deletion (di) that causes a frame shift downstream from the VP sequences and a loss of a stop codon. The resulting frame-shifted peptide precursor does not enter the secretory pathway in hypothalamic neurons, ther...

Topics

Adaptation, Physiological
Aging
Animals
Bacteria
Bacterial Physiological Phenomena
Humans
Mutation
Neurons
Rats
Rats, Brattleboro
Recombinant Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 9364662
DOI: 10.1016/s0166-2236(97)01143-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9364662-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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