Article
Ageing and the mismatch repair system.
Mechanisms of ageing and development - 20 Dec 2000
Ben Yehuda A, Globerson A, Krichevsky S, Bar On H, Kidron M, Friedlander Y, Friedman G, Ben Yehuda D
Abstract excerpt
Age-related accumulation of mutations has been extensively documented, and it has been proposed as one of the prominent causes of malignancies in old age. The present review is focused on the particular case of DNA mismatch repair system (MMR), that has drawn increased attention for its possible relevance to malignancy. We also report on our own observations on an age-associated genomic instability that develops...
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