Article
Identification of T-cell epitopes using allele-specific ligand motifs.
Behring Institute Mitteilungen - 1 Dec 1994
Stevanović S, Rammensee H G
Abstract excerpt
In order to facilitate the identification of T-cell epitopes as useful components of synthetic vaccines, we investigated the role of MHC molecules as the restriction element for the recognition of epitopes by the alpha beta receptor of T cells. MHC molecules are able to present thousands of different peptides to T cells, with all the peptides presented by one distinct type of MHC sharing common structural...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Epitopes
- HLA-D Antigens
- Histocompatibility Antigens Class I
- Histocompatibility Antigens Class II
- Humans
- Ligands
- Molecular Sequence Data
- Monophenol Monooxygenase