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Article

Effect of antagonists on DNA binding properties of the human estrogen receptor in vitro and in vivo.

Molecular endocrinology (Baltimore, Md.) - 1 May 1995

Metzger D, Berry M, Ali S, Chambon P

Abstract excerpt

Functional analyses, performed with the estrogen receptor (ER) isolated from different sources or produced with various expression systems, led to contradictory results concerning the role of estrogen (E2) and antiestrogens in ER DNA binding. Here we report the DNA-binding properties of the human ER and show that the wild type ER (HEG0) binds in vitro to an estrogen response element (ERE) as a dimer, irrespective...

Topics

Animals
Binding, Competitive
DNA
Estrogen Antagonists
Humans
Ions
Ligands
Mutation
Protein Binding
Receptors, Estrogen
Tamoxifen
Temperature

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transcription, Genetic

Source

Identifiers

PMID: 7565805
DOI: 10.1210/mend.9.5.7565805

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7565805-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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