Article
Inhibition of estrogen receptor-DNA binding by the "pure" antiestrogen ICI 164,384 appears to be mediated by impaired receptor dimerization.
Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 1990
Fawell S E, White R, Hoare S, Sydenham M, Page M, Parker M G
Abstract excerpt
Many estrogen-antagonist and -agonist ligands have been synthesized, some of which have proved clinically important in the treatment of hormone-dependent breast tumors and endocrine disorders. Here we show that the "pure" antiestrogen ICI 164,384 inhibits mouse estrogen receptor-DNA binding in vi...
Topics
- Amino Acid Sequence
- Animals
- Antibodies
- Blotting, Western
- Cell Line
- Chromosome Deletion
- Cloning, Molecular
- DNA
- Estradiol
- Estrogen Antagonists
- HeLa Cells
- Humans
- Molecular Sequence Data
- Mutation
- Peptides
- Polydeoxyribonucleotides
- Polyunsaturated Alkamides
- Protein Binding